Schizophrenia, Hypocretin (Orexin), and the Thalamocortical Activating System
نویسندگان
چکیده
منابع مشابه
Schizophrenia, hypocretin (orexin), and the thalamocortical activating system.
Diminished connectivity between midline-intralaminar thalamic nuclei and prefrontal cortex has been suggested to contribute to cognitive deficits that are detectable even in early stages of schizophrenia. The midline-intralaminar relay cells comprise the final link in the ascending arousal pathway and are selectively excited by the wake-promoting peptides hypocretin 1 and 2 (orexin A and B). Th...
متن کاملOverview of orexin/hypocretin system.
A series of recent studies has established the orexin/hypocretin system as a critical regulator of sleep/wake states. Its deficiency results in the sleep disorder narcolepsy in humans, dogs, and rodents. These findings have brought about the possibility of novel therapies for sleep disorders including narcolepsy and insomnia. Moreover, accumulating evidence indicates that the orexin/hypocretin ...
متن کاملSelective action of orexin (hypocretin) on nonspecific thalamocortical projection neurons.
As is evident from the pathological consequences of its absence in narcolepsy, orexin (hypocretin) appears to be critical for the maintenance of wakefulness. Via diffuse projections through the brain, orexin-containing neurons in the hypothalamus may act on a number of wake-promoting systems. Among these are the intralaminar and midline thalamic nuclei, which project in turn in a widespread man...
متن کاملHypocretin/orexin, sleep and narcolepsy.
The discovery that hypocretins are involved in narcolepsy, a disorder associated with excessive daytime sleepiness, cataplexy and unusually rapid transitions to rapid-eye-movement sleep, opens a new field of investigation in the area of sleep control physiology. Hypocretin-1 and -2 (also called orexin-A and -B) are newly discovered neuropeptides processed from a common precursor, preprohypocret...
متن کاملDepressive behavior and activation of the orexin/hypocretin system.
The orexin/hypocretin peptide signaling system plays a neuromodulatory role in motivation and stress; two critical components of depression. Although work has been done to identify links between orexin and depression, few specific neuroanatomical associations have been made. These studies have not investigated the relationship between orexin and orexin receptor expression in specific brain regi...
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ژورنال
عنوان ژورنال: Schizophrenia Bulletin
سال: 2006
ISSN: 0586-7614,1745-1701
DOI: 10.1093/schbul/sbm088